| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from an LCR (locus control region). <P>SOLUTION: The polynucleotide, which is an isolated polynucleotide, includes a methylation-free extended CpG island except the case that a DNase I hypersensitive site is associated with a promoter characterized in that the polynucleotide opens chromatin or maintains chromatin in an open state and facilitates the reproducible expression of an operably-linked gene, and deletes the DNase I hypersensitive site. <P>COPYRIGHT: (C)2009,JPO&INPIT</p> |
