HLA CLASS II PI4K2B MHAGS AND APPLICATION THEREOF

摘要

The invention identifies tumour - associated antigens that may be used for immunotherapy of malignancies in patients having under gone an allogeneic stem cell transplantation, whereby the therapy is mediated by induction of a graft versus tumour immune response. The invention provides peptides comprising autosomal HLA class II restricted minor histocompatibility antigens (mHags) and nucleic acid sequences coding therefor. The invention also provides T cell receptors and T lymphocytes capable of binding to these mHags. The molecules and cells of the invention can be used for treatment of subjects and manufacture of medicaments for the treatment of subjects suffering from malignancies expressing the PI4K2B protein.