发明名称 |
Inhibition of polo kinase by matrimony maintains G2 arrest in the meiotic cell cycle |
摘要 |
Matrimony (Mtrm) acts as a negative regulator of Polo kinase (Polo) during the later stages of G2 arrest. Indeed, both the repression of Polo expression until stage 11 and the inactivation of newly synthesized Polo by Mtrm until stage 13 play critical roles in maintaining and properly terminating G2 arrest. Our data suggest a model in which the eventual activation of Cdc25 by an excess of Polo at stage 13 triggers NEB and entry into prometaphase. In view of the foregoing, methods for modulating oocyte maturation are provided. More particularly, methods are provided for in vitro maturation of an oocyte. Further provided are methods for identifying functional orthologs of a Drosophila Matrimony polypeptide, as well as inhibitors thereof.
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申请公布号 |
US2009123934(A1) |
申请公布日期 |
2009.05.14 |
申请号 |
US20080288322 |
申请日期 |
2008.10.17 |
申请人 |
XIANG YOUBIN;JASPERSEN SUE;FLORENS LAURENCE;SMITH SARAH KENDALL;HAWLEY R SCOTT |
发明人 |
XIANG YOUBIN;JASPERSEN SUE;FLORENS LAURENCE;SMITH SARAH KENDALL;HAWLEY R. SCOTT |
分类号 |
C12Q1/68;C12N5/06;C12N9/99;C12Q1/48;G01N33/53 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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