发明名称 |
METHOD FOR PREDICTING RESPONSE TO TAMOXIFEN |
摘要 |
This invention relates, e.g., to a method for predicting the response of a subject having, or at risk of developing, breast cancer to Tamoxifen therapy. The method comprises measuring the amount of phosphorylation at residues S70 of Bcl-2, Y992 of EGFR, and/or Y527 of Src in a suitable sample from the subject, wherein a statistically significantly elevated level of phosphorylation at one or more of the three residues compared to a baseline value indicates that the subject is likely to be responsive to Tamoxifen therapy. |
申请公布号 |
WO2009014761(A3) |
申请公布日期 |
2009.05.14 |
申请号 |
WO2008US09105 |
申请日期 |
2008.07.28 |
申请人 |
GEORGE MASON INTELLECTUAL PROPERTIES, INC.;PETRICOIN, EMANUEL F. III;LIOTTA, LANCE A.;WULFKUHLE, JULIA D. |
发明人 |
PETRICOIN, EMANUEL F. III;LIOTTA, LANCE A.;WULFKUHLE, JULIA D. |
分类号 |
G01N33/50 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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