| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method for stimulating an immune response by administering to lymphoid cells either in a lymphoid organ or ex vivo, a nucleic acid molecule comprising a hematopoietic cell-specific expression element operationally linked to a nucleic acid sequence encoding one or more heterologous epitopes. <P>SOLUTION: The above heterologous epitope can be inserted into a complementarity-determining region of an immunoglobulin molecule. The invention also provides a nucleic acid molecule comprising a hematopoietic cell-specific expression element operationally linked to a nucleic acid sequence encoding a heterologous polypeptide. The invention additionally provides a method of treating a condition by administering a nucleic acid molecule comprising a hematopoietic cell-specific expression element operationally linked to a nucleic acid sequence encoding a heterologous polypeptide, wherein the nucleic acid molecule is targeted to a hematopoietic cell. <P>COPYRIGHT: (C)2009,JPO&INPIT |
