| 摘要 |
PROBLEM TO BE SOLVED: To provide crystalline 11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl)-dibenzo[b, f][1, 4]thiazepine which can be used for the treatment of psychoses. SOLUTION: The crystalline 11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl)-dibenzo[b, f][1, 4]thiazepine (I) can be manufactured by crystallizing 11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl)-dibenzo[b, f][1, 4]thiazepine from a non-aromatic solvent, for example, ethyl acetate, isobutyl acetate, methyl isobutyl ketone or methyl t-butyl ether, preferably in the absence of water. The manufactured crystalline substance may be converted into a pharmaceutically acceptable salt, for example, a fumarate. COPYRIGHT: (C)2009,JPO&INPIT
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