| 发明名称 |
SPECIFIC BINDING PROTEIN AND USE THEREOF |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a specific binding member, particularly antibody and active fragment thereof, which recognizes an aberrant post-translationally modified, particularly an aberrant glycosylated form of the EGFR(epidermal growth factor receptor). <P>SOLUTION: Provided is the specific binding member being particularly an isolated specific binding member which recognizes an EGFR epitope which does not demonstrate any amino acid sequence alterations or substitutions from normal EGFR and which is found in tumorigenic, hyperproliferative or abnormal cells and is not found in normal cells. <P>COPYRIGHT: (C)2009,JPO&INPIT |
| 申请公布号 |
JP2009100745(A) |
申请公布日期 |
2009.05.14 |
| 申请号 |
JP20080292842 |
申请日期 |
2008.11.14 |
| 申请人 |
LUDWIG INST FOR CANCER RESEARCH |
发明人 |
OLD LLOYD J;JOHNS TERRANCE GRANT;PANOUSIS CON;SCOTT ANDREW MARK;RENNER CHRISTOPH;RITTER GERD;JUNGBLUTH ACHIM;STOCKERT ELISABETH;COLLINS PETER;CAVENEE WEBSTER K;HUANG HUEI-JEN;BURGESS ANTHONY WILKS;NICE EDOUARD COLLINS |
| 分类号 |
C12N15/09;G01N33/50;A61K39/00;A61K39/395;A61K45/00;A61K51/00;A61P35/00;C07K16/28;C07K16/30;C07K16/32;C07K16/46;C07K19/00;C12N1/19;C12N1/21;C12N5/10;C12P21/08;G01N33/15;G01N33/53;G01N33/566;G01N33/574 |
主分类号 |
C12N15/09 |
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