发明名称 |
INHIBITION OF THE SH2-DOMAIN CONTAINING PROTEIN TYR-PHOSPHATASE, SHP-1, TO ENHANCE VACCINES |
摘要 |
The invention describes the use of dendritic cell vaccines, wherein SHP-1 expression or activity is modulated in the dendritic cell. In particular, the invention provides dendritic cells (DC) transduced with an SHP1-shRNA adenovirus, or dominant negative (dn-SHP-1) or constitutively active (ca-SHP-1), and pulsed with an antigen. The methods and compositions of the invention are used for the prevention and/or treatment of cancers, other cell proliferation diseases and conditions, diseases caused by a pathogen, or autoimmune disorders.
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申请公布号 |
US2009123501(A1) |
申请公布日期 |
2009.05.14 |
申请号 |
US20080122146 |
申请日期 |
2008.05.16 |
申请人 |
BAYLOR COLLEGE OF MEDICINE |
发明人 |
LEVITT JONATHAN;RAMACHANDRAN INDU R.;SLAWIN KEVIN M. |
分类号 |
A61K39/00;A61K31/7088;A61K35/12 |
主分类号 |
A61K39/00 |
代理机构 |
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地址 |
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