DUSP4 as clinically relevant epigenetic marker and therapeutic target in gliomas and other tumors

摘要

The present invention provides a method for diagnosis or prognosis of a cancer and a method for prediction of the responsiveness of certain tumor types, said methods comprising determining the methylation degree, i.e. the detection of methylated CpG sites in of the DUSP4 / MKP2 gene/promoter. The invention further provides a method for determination of the methylation degree of the promoter region of the dual-specificity phosphatase 4/map kinase phosphatase 2 ( DUSP4 / MKP2) gene, which is suitable for prediction of the responsiveness of certain tumor types and for diagnosis or prognosis of cancer. Amplification products and primers which may be used in said method and kits for performing the method are also provided.