| 摘要 |
<p>Catenated molecule for modulating the activity of the human or animal immune system, obtained by: providing a 5-phosphorylated oligonucleotide; alcohol precipitation or lyophilization in the presence of magnesium chloride until a dry residue is obtained and subsequently resuspension in a buffer solution; adding a T4-DNA ligase, where a reaction mixture is formed; and incubating the reaction mixture at 37[deg] C for at least 30 minutes. Independent claims are included for: (1) a combination agent comprising a molecule and a chemotherapeutic agent comprising antibodies, alkylants, platinum analogues, intercalents, antibiotics, mitosis inhibitor, taxane, topoisomerase inhibitor, antimetabolites and/or L-asparaginase, hydroxycarbamide, mitotane and/or amanitine; (2) a kit comprising the molecule and/or combination agent and optionally an information for combining the contents of the kit; and (3) a pharmaceutical agent comprising the molecule and/or combination agent optionally with a carrier. ACTIVITY : Immunomodulator; Cytostatic; Immunostimulant. MECHANISM OF ACTION : Vaccine.</p> |
