发明名称 |
IDENTIFICATION OF A MICRO-RNA THAT ACTIVATES EXPRESSION OF BETA-MYOSIN HEAVY CHAIN |
摘要 |
The present invention relates to the identification of a microRNA, miR-208, that induces the expression of ²-myosin heavy chain (²-MHC) and represses fast skeletal muscle contractile protein genes. Inhibition of this function is proposed as a treatment for cardiac fibrosis, hypertrophy and/or heart failure, and augmentation of this function can be used to repress slow fiber genes and activate fast fiber genes in the treatment of musculoskeletal disorders. |
申请公布号 |
EP2056882(A2) |
申请公布日期 |
2009.05.13 |
申请号 |
EP20070813595 |
申请日期 |
2007.07.31 |
申请人 |
BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
OLSON, ERIC;VAN ROOIJ, EVA |
分类号 |
A61K48/00;A61P9/04;A61P9/10 |
主分类号 |
A61K48/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|