发明名称 |
SUCCINIC ACID DIESTER DERIVATIVE, PROCESS FOR PRODUCTION THEREOF, AND USE OF THE DERIVATIVE IN THE PRODUCTION OF PHARMACEUTICAL PREPARATION |
摘要 |
The present invention provides with a process of preparing an optically active succinimide derivative, which is a key intermediate for production of ranirestat. A compound (3) is easily prepared by treating the derivative of succinic acid diester of the formula (2):
wherein R 1 is an amino group protected with a group removed by hydrogenolysis or a tert-butoxycarbonylamino group and R 2 is an ethyl group optionally substituted with one or two methyl group(s) at ±-position, provided that R 2 is not a tert-butyl group when R 1 is a tert-butoxycarbonylamino group; with alkali metal alkoxide and the compound (3) can be an important intermediate for production of ranirestat.
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申请公布号 |
EP2058300(A1) |
申请公布日期 |
2009.05.13 |
申请号 |
EP20070806339 |
申请日期 |
2007.08.30 |
申请人 |
DAINIPPON SUMITOMO PHARMA CO., LTD.;KATAYAMA SEIYAKUSYO CO. LTD. |
发明人 |
INAGAKI, TAKASHI;YAMAKAWA, YOSHIKAZU |
分类号 |
C07C271/22;C07B61/00;C07C269/06;C07D207/416 |
主分类号 |
C07C271/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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