| 发明名称 |
Phosphospecific PAK antibodies and diagnostic kits |
| 摘要 |
<p>The present invention relates to the use of phosphorylated p21-activated protein kinases (PAK), especially PAK4, as biomarkers of tumorogenesis. The present invention contemplates the use of phosphospecific antibodies for detecting phosphorylated PAK from mammalian biopsies, as well as screening assays for identifying compounds that modulate PAK activity. Also contemplated is a method for determining a subset of a given population that is amenable to treatment with a compound that modulates PAK activity.</p> |
| 申请公布号 |
EP2055786(A3) |
申请公布日期 |
2009.05.13 |
| 申请号 |
EP20090153048 |
申请日期 |
2003.11.20 |
| 申请人 |
SUGEN, INC. |
发明人 |
SMEAL, TOD R.;CALLOW, MARINELLA G.;JALLAL, BAHIJA |
| 分类号 |
C12Q1/48;C07K16/40;C07K16/44;G01N33/574 |
主分类号 |
C12Q1/48 |
| 代理机构 |
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