FREEZE-DRIED PREPARATION OF 1-METHYLCARBAPENEM

摘要

An object of the present invention is to produce a lyophilized preparation comprising (1R,5S,6S)-6-[(1R)-1-hydroxyethyl]-1-methyl-2-[(2S,4S)-2-[(3S)-3-(2-guanidinoacetylamino)pyrrolidin-1-ylcarbonyl]-1-methylpyrrolidin-4-ylthio]-1-carbapen-2-em-3-carboxylic acid or a pharmacologically acceptable salt thereof as a carbapenem compound which has a 1-alkylpyrrolidine structure and possesses a superior antimicrobial activity, and sodium chloride.