发明名称 |
Sugar chain-containing albumin, production method and use thereof |
摘要 |
Glycosylated albumin as a drug carrier for a DDS targeting the liver (particularly kupffer's cell) can be provided by mutating a DNA encoding albumin to encode a mutant albumin containing a partial amino acid sequence permitting glycosylation modification by eukaryotic cell, preferably a consensus sequence of N-linked sugar chain, introducing an expression vector containing the mutant DNA into a host eukaryotic cell, preferably a host cell permitting addition of a high-mannose type sugar chain, culturing the obtained transformant, and recovering a glycosylated albumin protein from the obtained culture.
|
申请公布号 |
EP2058331(A1) |
申请公布日期 |
2009.05.13 |
申请号 |
EP20070120396 |
申请日期 |
2007.11.09 |
申请人 |
NIPRO CORPORATION |
发明人 |
NAKAJOU, KEISUKE;KATAYAMA, NAOHISA;KAI, TOSHIYA;OTAGIRI, MASAKI |
分类号 |
C07K14/765;A61K47/48 |
主分类号 |
C07K14/765 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|