发明名称 |
2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives useful as inhibitors of beta-secretase (BACE) |
摘要 |
The present invention is directed to novel 2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of beta-secretase, also known as beta-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.
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申请公布号 |
US7531545(B2) |
申请公布日期 |
2009.05.12 |
申请号 |
US20060552792 |
申请日期 |
2006.10.25 |
申请人 |
JANSSEN PHARMACEUTICA, N.V. |
发明人 |
BAXTER ELLEN E.;CREIGHTON CHRISTOPHER JOHN;HUANG YIFANG;LUO CHI;PARKER MICHAEL H.;REITZ ALLEN B.;REYNOLDS CHARLES H.;ROSS TINA MORGAN;STROBEL ERIC D.;TOUNGE BRETT A. |
分类号 |
A61K31/519;A61P25/28;C07D471/04 |
主分类号 |
A61K31/519 |
代理机构 |
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