发明名称 PHARMACEUTICAL COMPOSITION CONTAINING DICLOFENAC AND 2-HYDROXYPROPYL-.BETA.-CYCLODEXTRIN
摘要 A method of preparing an injectable pharmaceutical or veterinary compositio n which comprises either diclofenac or a salt thereof and 2-hydroxypropyl beta-cyclodextrin, or an inclusion complex of diclofenac or a salt thereof a nd 2-hydroxypropyl beta-cyclodextrin, includes the step of dissolving either th e diclofenac or salt thereof and the 2-hydroxypropyl beta-cyclodextrin, or the inclusion complex, in water to form a solution, the water having been acidified to a pH such that the pH of the solution is from 6,0 to 8,5 inclusive, in th e absence of a phosphate buffer. The composition so produced has good stabilit y on storage.
申请公布号 CA2136492(C) 申请公布日期 2009.05.12
申请号 CA19942136492 申请日期 1994.11.23
申请人 发明人 BODLEY, MARK DAVID;GLINTENKAMP, LUETA ANN;PENKLER, LAWRENCE JOHN;VAN OUDTSHOORN, MICHIEL COENRAAD BOSCH
分类号 A61K9/08;A61K31/196;A61K31/19;A61K31/195;A61K47/40;A61K47/48;A61P25/04;A61P29/00 主分类号 A61K9/08
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