发明名称 |
Non self-inactivating, expression targeted retroviral vectors |
摘要 |
The present invention relates to a retroviral vector undergoing promoter conversion comprising a 5'LTR region of the structure U3-R-U5; one or more sequences selected from coding and non-coding sequences; and a 3'LTR region comprising a completely or partially deleted U3 region wherein said deleted U3 region is replaced by a polylinker sequence, followed by the R and U5 region. The retroviral vector undergoes promoter conversion and is useful as a gene transfer vehicle for targeted gene therapy.
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申请公布号 |
US7531353(B1) |
申请公布日期 |
2009.05.12 |
申请号 |
US19970808827 |
申请日期 |
1997.02.28 |
申请人 |
GSF-FORSCHUNGSZENTRUM FUR UNWELT UND GESUNDHEIT GMBH |
发明人 |
GUENZBURG WALTER HENRY;SALLER ROBERT MICHAEL |
分类号 |
C12N5/10;C12N15/09;A61K35/76;A61K48/00;C12N7/00;C12N15/00;C12N15/11;C12N15/86;C12N15/867 |
主分类号 |
C12N5/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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