发明名称 |
A MORTIERELLA ALPINA GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE FOR ALTERATION OF POLYUNSATURATED FATTY ACIDS AND OIL CONTENT IN OLEAGINOUS ORGANISMS |
摘要 |
Glycerol-3-phosphate o-acyltransferase (GPAT) participates in the first step of oil biosynthesis and is expected to play a key role in altering the quantity of long-chain polyunsaturated fatty acids (PUFAs) produced in oils of oleaginous organisms. The present application provides a nucleic acid fragment isolated from Mortierella alpina encoding a GPAT that is suitable for use in the manufacture of oils enriched in omega fatty acids in oleaginous organisms. Most desirably, the substrate specificity of the instant GPAT will be particularly useful to enable accumulation of long-chain PUFAs having chain lengths equal to or greater than C20 in oleaginous yeast, such as Yarrowia lipolytica. |
申请公布号 |
WO2006052824(A3) |
申请公布日期 |
2009.05.07 |
申请号 |
WO2005US40167 |
申请日期 |
2005.11.03 |
申请人 |
E.I. DUPONT DE NEMOURS AND COMPANY;MACOOL, DANIEL, JOSEPH;XUE, ZHIXIONG |
发明人 |
MACOOL, DANIEL, JOSEPH;XUE, ZHIXIONG |
分类号 |
C12N9/10;C07H21/04;C12N1/15;C12N1/16;C12N15/70;C12N15/74;C12P7/64 |
主分类号 |
C12N9/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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