发明名称 |
USE OF NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID, AND PROCESS FOR PRODUCTION OF THE SAME |
摘要 |
<p>The object is to provide a reagent for detecting amyloid in a biological tissue, which comprises a compound having affinity for amyloid and reduced in its toxicity such as mutagenicity, and which can detect amyloid in vitro and in vivo with high sensitivity. Thus, disclosed is a reagent for detecting amyloid deposited in a biological tissue, which comprises a compound represented by the formula (1) or a salt thereof. [Chemical formula] (1) wherein A1, A2, A3 and A4 independently represent a carbon or a nitrogen; R3 represents a group represented by the formula shown below; R1 represents a radioactive halogen substituent; m represents an integer of 0 to 4; and n represents an integer of 0 or 1, provided that at least one of A1, A2, A3 and A4 is a carbon and then R3 binds to the at least one of A1, A2, A3 and A4 which is a carbon [Chemical formula]</p> |
申请公布号 |
WO2009057575(A1) |
申请公布日期 |
2009.05.07 |
申请号 |
WO2008JP69501 |
申请日期 |
2008.10.28 |
申请人 |
NIHON MEDI-PHYSICS CO., LTD.;TANIFUJI, SHIGEYUKI;NAKAMURA, DAISAKU;TAKASAKI, SHINYA;OKUMURA, YUKI |
发明人 |
TANIFUJI, SHIGEYUKI;NAKAMURA, DAISAKU;TAKASAKI, SHINYA;OKUMURA, YUKI |
分类号 |
A61K51/00;C07D471/04 |
主分类号 |
A61K51/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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