| 摘要 |
<p>The present disclosure relates to processes for preparing metal-free, mono-dispersed polymers of amino acids. The polymers include homopolymers, random copolypeptides, block copolypeptides, block copolymers with at least one peptidyl block, grafted copolypeptides, and polypetidyl dendrimers. The disclosed process does not make use of a heavy metal catalyst, inter alia, copper or nickel containing reagents. The disclosed process encompasses a "living polymerization" such that the growth of each polymer chain is not truncated or otherwise halted by undesirable side reactions or limitations due to the length or size of the growing polymer chain, provides amino acid comprising polymers having a narrow polydispersity, is conducted at lower temperatures, and avoids the premature secondary folding that inhibits the formation of polymers having a low polydispersity index. This abstract is intended to provide key words and search terms for use in searching patent and patent application data bases and is not intended to limit the subject matter of the disclosure.</p> |
