5-SUBSTITUTED INDOL-3-CARBOXYLIC ACID DERIVATIVES EXHIBITING ANTIVIRAL ACTIVITY A METHOD FOR THE PRODUCTION AND USE THEREOF

摘要

The invention relates to novel antiviral compounds of general formula (I), where B is -N(R)2 or -O-(CH2)nN(R)2 groups, in which n is a whole number selected from 0, 1, 2, 3 and 4, each R is independently selected from C1-4 alkyl and can be identical or different, or both groups R together with a nitrogen atom, to which they are bonded, form a 5-6-membered heterocyclic ring containing 1-2 heteroatoms selected from nitrogen, oxygen and sulphur, such as pyrrolidine, piperidine, piperazine, morpholine or thyomorpholine, at which each of above-mentioned heterocyclic rings can be substituted by C1-4 alkyl, phenyl, benzyl, phenetyl, a carbonylamino -COOC1-4 alkyl group or the carbonylamino -COOC1-4 alkyl group and phenyl, which also can be substituted and have substituents selected from halogen, C1-4 alkyl, C1-4 alkoxy, and alkyl in said groups can be linear or branched; R1 is C1-4 alkoxy, phenyl optionally substituted by C1-4 alkyl or C1-4 alkoxy, halogen atoms, naphthyl; R2 is C1-4 alkyl, -S-phenyl, -S-benzyl, -O-phenyl, O-benzyl, wherein in each of the above-mentioned groups the phenyl ring is optionally substituted by C1-4 alkyl, C1-4 alkoxy, halogen atoms, or R2 is an -NR3R4 group, in which R3 and R4, each is independently selected from C1-4 alkyl and can be identical or different, or both R3 and R4 groups together with a nitrogen atom, to which they are bonded, form a 5-6-membered nitrogen-containing heterocyclic ring having the above mentioned value for the N(R)2 group; X is hydrogen or a halogen atom selected from Br, Cl, and I or pharmaceutically acceptable salts thereof. Intermediate products of general formula (II) and a method for producing the inventive compounds are also disclosed.