PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING FIBROSIS

摘要

The present invention relates to a pharmaceutical composition for preventing or treating fibrosis comprising (a) a therapeutically effective amount of a transglutaminase 2 (TGase2) inhibitor or N-acetylcysteine (NAC); and (b) a pharmaceutically acceptable carrier, and a method for screening a substance to prevent or treat fibrosis. The present invention definitely demonstrates molecular mechanism underlying fibrosis development and provides a novel molecular target of fibrosis therapeutics. Moreover, fibrosis therapeutics of this invention effectively prevent or treat fibrosis with much higher safety.