摘要 |
<p>Modified relaxin polypeptides are disclosed wherein the B chain comprises the core sequence CGRxxxRxxI/VxxCG (SEQ ID NO: 1), specifically KLCGRELVRAQIAIC. Chimeric polypeptides comprising a B chain with the core sequence CGRxxxRxxFVxxCG (SEQ ID NO: 1) and an A chain from a heterologous relaxin family peptide are also disclosed. Specifically, chimeric polypeptides comprising a B chain from relaxin-2, and an A chain from relaxin- 1, relaxin-3, insulin, IGF-I, IGF-II, INSL3, INSL4, INSL5 or INSL6, are disclosed.</p> |
申请人 |
HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE;BATHGATE, ROSS, ALEXANDER, DAVID,;HOSSAIN, MOHAMMED, AKHTER;SAMUEL, CHRISHAN, SURENDRAN;WADE, JOHN, DESMOND;TREGEAR, GEOFFREY, W |
发明人 |
BATHGATE, ROSS, ALEXANDER, DAVID;HOSSAIN, MOHAMMED, AKHTER;SAMUEL, CHRISHAN, SURENDRAN;WADE, JOHN, DESMOND;TREGEAR, GEOFFREY, W |