| 摘要 |
<p>Disclosed are 17-methylene steroids of formula (I), in which R4 is a halogen atom or a pseudohalogen, R10 is a hydrogen atom or a straight-chain or branched C1-4-alkyl group, R20 and R20a are, independently of one another, a hydrogen atom, a straight-chain or branched C1-4-alkyl or hydroxy-C1-4-alkyl group or one of the radicals R20 and R20a is a hydrogen atom, a straight-chain or branched C1-4-alkyl or hydroxy-C1-4-alkyl group, and the other radical is a halogen atom or a pseudohalogen, methods for the production thereof and pharmaceutical compositions containing these compounds. The inventive compounds have an active profile with a hybrid character of such that they act as inhibitors of the 5 alpha -reductase and, at the same time, as gestagens. The inventive compounds combined with other hormonal substances such as estrogen, testosterone or a potent androgen are suited as contraceptives for women and men.</p> |
