发明名称 |
Compounds exhibiting glucagon antagonist and GLP-1 agonist activity |
摘要 |
Glucagon analogs are disclosed that exhibit both glucagon antagonist and GLP-1 agonist activity. In one embodiment, the glucagon antagonist/GLP-1 agonist comprises a modified amino acid sequence of native glucagon, in which the first one to five N-terminal amino acids of native glucagon is deleted and in which the alpha helix is stabilized. |
申请公布号 |
AU2008318876(A1) |
申请公布日期 |
2009.05.07 |
申请号 |
AU20080318876 |
申请日期 |
2008.10.27 |
申请人 |
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION |
发明人 |
BIN YANG;CHENGUANG OUYANG;RICHARD D. DIMARCHI |
分类号 |
A61K38/00;A61K39/00;C07K14/605 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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