METHOD FOR HIGH-LEVEL SECRETION AND PRODUCTION OF PROTEIN

摘要

Disclosed is a means for secreting and producing a protein, particularly a protein having a complicated structure (e.g., an antibody), in a host cell (e.g., an yeast cell) at a high level. Specifically disclosed are: a transformed host cell having one or more chaperone protein genes; and a method for secreting and producing a foreign protein at a high level by suppressing an O-type sugar chain which is specific to a host cell such as an yeast cell by using the transformed host cell.