发明名称 NEW DHA DERIVATIVES AND THEIR USE AS MEDICAMENTS
摘要 The present disclosure relates to compounds of the general Formula (I): wherein R1 and R2 are the same or different and are chosen from a hydrogen atom, a hydroxy group, an alkyl group, a halogen atom, an alkoxy group, an acyloxy group, an acyl group, an alkenyl group, an alkynyl group, an aryl group, an alkylthio group, an alkoxycarbonyl group, an alkylsulfinyl group, an alkylsulfonyl group, an amino group, and an alkylamino group; and any pharmaceutically acceptable salt, solvate, complex, or pro-drug thereof; and their use as medicaments for the treatment of various diseases and conditions, for example, reduction of elevated triglyceride levels, i.e., hypertriglyceridemia, reduction of non-HDL cholesterol, reduction of glucose and HbAIc, and improvement of insulin resistance. The present disclosure also relates to a pharmaceutical composition comprising compounds of formula (I), as well as to processes for preparing compounds according to formula (I).
申请公布号 WO2009056983(A1) 申请公布日期 2009.05.07
申请号 WO2008IB03666 申请日期 2008.10.30
申请人 PRONOVA BIOPHARMA NORGE AS;HOLMEIDE, ANNE KRISTIN;HOVLAND, RAGNAR 发明人 HOLMEIDE, ANNE KRISTIN;HOVLAND, RAGNAR
分类号 C07C69/587;A61K31/19;A61P3/10;C07C69/734 主分类号 C07C69/587
代理机构 代理人
主权项
地址