A MULTICOMPONENT OR MONOCOMPONENT VACCINE TO BE USED AGAINST CHAGAS DISEASE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, PROCEDURE FOR THE OBTENTION OF IMMUNOGEN OF SAID VACCINES, AND NUCLEIC ACID USED IN SAID PROCEDURE

摘要

The main objective of the present invention is to obtain a vaccine against the Chagas disease, capable of stimulating the immune response against the trans- sialidase virulence factor of the Trypanosoma Cruzi parasite, distinguished by the fact that said vaccine comprises a multicomponent vaccine for the Chagas disease (tripanosomiasis americana) distinguished by the fact that it comprises: (a) an immunogenic portion formed by one or more recombinant or synthetic polypeptides or fractions of thereof and (b) one or more polynucleotides including the regions that codifying one or more immunogenic polypeptides, both portions for the Trypanosoma Cruzi derivates (i.e., T. Cruzi and or a conserved region common to many of them) where the vaccine administration is a protection against the parasite infection, eliminates it or reduces the clinical consequences of said infection. Another objective of the present invention is a monocomponent vaccine against the Chagas disease comprising at least one component selected among an immunogenic portion formed by one or more recombinant or synthetic polypeptides or fractions of them and a group of polynucleotides including the regions that codifying one or more immunogenic polypeptides derived from Trypanosoma Cruzi (i.e. a T. Cruzi and /or a conserved region common to many of them) where the immunogenic portion or the polynucleotides group stimulates an antibody response, of CD4+ Th1 biased T cells or CD8+ T cells against the Trypanosoma Cruzi. This invention also includes: the pharmaceutical compositions containing said multicomponent and monocomponent vaccines, the procedures for obtaining the immunogen portion of said vaccines and the nucleic acid used in the procedure.