| 摘要 |
The present invention of a segmented release device (sandwich construction with reservoir) for molecules (active compounds, medicaments, diagnostic, therapeutic and chemical reagents) is based on a construction which makes possible a constant release rate through diffusion-permeable intersegment films partially or completely filled with liquid of the neighboring media. The molecules pass here from the reservoir of the device into the outer medium by diffusion exclusively through the intersegment films. These intersegment films are adjustable in their thickness and composition in the manner specified in each case. The release rate can be determined in advance and thus also calculated within wide limits by the structure and geometry of the segmented device and by the number, composition and dimensions of the thin intersegment films. The device according to the present invention allows the adjustment of an extremely precise release rate of the molecules. By means of this, an optimal adaptation of the release rate per prescription present in each case can be carried out. On the part of the molecule, only the knowledge of the solubility and of the diffusion coefficient is of outstanding importance here. Directional dependence of the release is achievable by the shape of segments. Here, areas which are nearer to the reservoir have a shorter diffusion path than areas having a greater distance. The release capacity can approximately reach the capacity of the reservoir.
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