发明名称 |
Rationally-designed single-chain meganucleases with non-palindromic recognition sequences |
摘要 |
Disclosed are rationally-designed, non-naturally-occurring meganucleases in which a pair of enzyme subunits having specificity for different recognition sequence half-sites are joined into a single polypeptide to form a functional heterodimer with a non- palindromic recognition sequence. The invention also relates to methods of producing such meganucleases, and methods of producing recombinant nucleic acids and organisms using such meganucleases. |
申请公布号 |
AU2008318430(A1) |
申请公布日期 |
2009.05.07 |
申请号 |
AU20080318430 |
申请日期 |
2008.10.31 |
申请人 |
PRECISION BIOSCIENCES, INC. |
发明人 |
DEREK JANTZ;JAMES JEFFERSON SMITH |
分类号 |
C12N9/22 |
主分类号 |
C12N9/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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