发明名称 Reactions on a solid surface
摘要 The present invention relates to compositions and methods for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. The present invention relates to methods for forming a nucleic acid cleavage structure on a solid support and cleaving the nucleic acid cleavage structure in a site-specific manner. For example, in some embodiments, a 5' nuclease activity from any of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
申请公布号 US7527928(B2) 申请公布日期 2009.05.05
申请号 US20020309584 申请日期 2002.12.04
申请人 THIRD WAVE TECHNOLOGIES, INC. 发明人 NERI BRUCE P.;HALL JEFF G.;LYAMICHEV VICTOR;SMITH LLOYD M.
分类号 C12Q1/68;C12N9/22 主分类号 C12Q1/68
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