发明名称 |
Kombinationer, der omfatter antimuskarine midler og beta-adrenerge agonister |
摘要 |
<p>Combination (I) comprises a phosphodiesterase inhibitor 4 (PDE4) (A) and an antagonist of M3 muscarinic receptors (B) (3(R)-(2-hydroxy-2, 2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo [2.2.2] octane), in the form of a salt having an anion X (anion of a mono or polyvalent acid). An independent claim is also included for a method of treating a patient suffering from or susceptible to a respiratory disease or condition which responds to M3 antagonism comprising simultaneous, concurrent, separate or sequential administration of (I). ACTIVITY : Antiasthmatic; Respiratory-Gen.; Antiinflammatory. MECHANISM OF ACTION : Phosphodiesterase-4 inhibitor; Muscarinic receptors antagonist; Leukotriene-D4 antagonist; Neurokinin-1- receptor antagonist; Epidermal growth factor receptor kinase inhibitor; Beta-2 agonist; p38 Kinase inhibitor.</p> |
申请公布号 |
DK1763368(T3) |
申请公布日期 |
2009.05.04 |
申请号 |
DK20050750538T |
申请日期 |
2005.05.31 |
申请人 |
LABORATORIOS ALMIRALL, S.A. |
发明人 |
GRAS ESCARDO, JORDI;RYDER, HAMISH;ORVIZ DIAZ, PIO;LLENAS CALVO, JESUS |
分类号 |
A61K45/00;A61K31/137;A61K31/167;A61K31/439;A61K31/573;A61K31/58;A61K31/655;A61K45/06;A61P11/00;A61P11/06;A61P11/08 |
主分类号 |
A61K45/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|