发明名称 METHOD FOR MAKING SOLID DISPERSIONS OF HIGHLY CRYSTALLINE THERAPEUTIC COMPOUNDS
摘要 A process for preparing solid dispersions of highly crystalline compounds. The highly crystalline or thermally labile therapeutic compounds are processed in an extruder in combination with a solubilizing agent and optionally a plasticizer. The resulting extrudate features the therapeutic compound in an amorphous state. Particularly useful as the solubilizing agents are surfactants such as poloxamers.
申请公布号 KR20090042961(A) 申请公布日期 2009.05.04
申请号 KR20097005216 申请日期 2007.08.14
申请人 NOVARTIS AG 发明人 GHOSH INDRAJIT;SNYDER JENNIFER;TONG WEI QIN;VIPPAGUNTA SUDHA
分类号 A61K9/14;A61K9/16;A61K47/34;A61P35/00 主分类号 A61K9/14
代理机构 代理人
主权项
地址