发明名称 |
método para a produção de ácidos dicarboxìlicos. |
摘要 |
The present invention is an economical fermentation method for the production of carboxylic acids comprising the steps of a) inoculating a medium having a carbon source with a carboxylic acid-producing organism; b) incubating the carboxylic acid-producing organism in an aerobic atmosphere to promote rapid growth of the organism thereby increasing the biomass of the organism; c) controllably releasing oxygen to maintain the aerobic atmosphere; d) controllably feeding the organism having increased biomass with a solution containing the carbon source to maintain the concentration of the carbon source within the medium of about 0.5 g/L up to about 1 g/L; e) depriving the aerobic atmosphere of oxygen to produce an anaerobic atmosphere to cause the organism to undergo anaerobic metabolism; f) controllably feeding the organism having increased biomass a solution containing the carbon source to maintain the concentration of the carbon source within the medium of >/=1 g/L; and g) converting the carbon source to carboxylic acids using the anaerobic metabolism of the organism. |
申请公布号 |
BR9806822(B1) |
申请公布日期 |
2009.05.05 |
申请号 |
BR19989806822 |
申请日期 |
1998.01.30 |
申请人 |
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发明人 |
NHUAN PHU NGHIEM;MARK DONNELLY;CYNTHIA S. MILLARD;LUCY STOLS |
分类号 |
C12N15/09;C12P7/40;C12N1/21;C12N1/38;C12N9/04;C12P7/06;C12P7/44;C12P7/46;C12P7/54;C12R1/19;C12R1/225 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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