| 摘要 |
PROBLEM TO BE SOLVED: To provide a unit with a high productivity, despite the use of sensitive cells and a product which tends to deteriorate. SOLUTION: The unit for carrying out continuous high cell density fermentation comprises a pre-culture fermenter (9); a substrate storage tank (1); a production fermenter (2) and a sedimentation separator (4) and a harvest vessel (6), wherein the sedimentation separator has a separator surface area of A<SB>th</SB>/V<SB>s</SB>≥30 m<SP>2</SP>/m<SP>3</SP>based on the separator volume, wherein the sedimentation separator is such that the sedimentation separator has a conical or pyramidal receiving chamber and the inflow into the receiving chamber of the sedimentation separator takes place via at least two conduits arranged radially, tangentially in an identical direction or tangentially in opposite directions, where the conduits are arranged, in a regular fashion over the cross-section. COPYRIGHT: (C)2009,JPO&INPIT
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