发明名称 |
METHODS AND COMPOSITIONS FOR IDENTIFYING A PEPTIDE HAVING AN INTERMOLECULAR INTERACTION WITH A TARGET OF INTEREST |
摘要 |
This invention provides, in one embodiment, a recombinant virus or a recombinant virus library wherein each virus comprises a protein involved in viral attachment or infection, a polypeptide which differs by at least a single amino acid from another peptide or polypeptide in the library, and a modified cleavage site that is proximal to the peptide and the protein, wherein the cleavage site is modified such that a compound mediating cleavage has a reduced binding affinity for it as compared to a non-modified cleavage site. The invention further provides a target of interest complex comprising a protease, a target of interest involved in an intermolecular interaction, and a flexible linker that attaches the protease and target of interest. The invention further provides uses thereof, including a method for identifying a peptide which has an intermolecular interaction with a target of interest or identifying the agonistic or antagonistic feature of a peptide that has an intermolecular reaction with a target of interest. |
申请公布号 |
WO2007010525(A3) |
申请公布日期 |
2009.04.30 |
申请号 |
WO2006IL00815 |
申请日期 |
2006.07.12 |
申请人 |
AEBI LTD.;MORAD, ILAN;ITZHAKI, HANAN |
发明人 |
MORAD, ILAN;ITZHAKI, HANAN |
分类号 |
C40B40/02;C40B40/10;G01N33/53 |
主分类号 |
C40B40/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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