IP-10 antibodies and their uses

摘要

Disclosed is an isolated monoclonal antibody, or an antigen-binding portion thereof, wherein the antibody specifically binds to human IP-10 and exhibits the following properties: (a) inhibits binding of IP-10 to CXCR3; (b) inhibits IP-10 induced calcium flux; (c) inhibits IP-10 induced cell migration; (d) cross-reacts with rhesus monkey IP-10; (e) does not cross-react with mouse IP-10; (f) does not cross react with human MIG; (g) does not cross react with human ITAC.