| 发明名称 |
COMPOSITIONS AND METHODS RELATED TO TIM 3, A TH1-SPECIFIC CELL SURFACE MOLECULE |
| 摘要 |
The present invention provides compositions and methods useful for promoting or reducing T-cell trafficking to a target tissue. Also provided are compositions and methods useful for promoting or inhibiting antigen-presenting cell (APC) activation. The invention is related to discovery of functional characteristics of TIM-3, a molecule that is preferentially expressed on the surface of Th1 cells. The methods are useful for treating disorders including cancer, infectious disease, allergy, asthma, and autoimmune disease.
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| 申请公布号 |
US2009110687(A1) |
申请公布日期 |
2009.04.30 |
| 申请号 |
US20080276977 |
申请日期 |
2008.11.24 |
| 申请人 |
THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
KUCHROO VIJAY;MONNEY LAURENT;GAGLIA JASON L.;GREENFIELD EDWARD A.;FREEMAN GORDON J.;WALDNER HANSPETER |
| 分类号 |
A61K39/395;C12N15/09;A61K38/00;A61K45/00;A61P31/04;A61P35/00;A61P43/00;C07K16/28;C12N5/06;C12N15/00 |
主分类号 |
A61K39/395 |
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