PYRIDONE-SUBSTITUTED-DIHYDROPYRAZOLOPYRIMIDINONE DERIVATIVE

摘要

Disclosed are: a compound represented by the formula (I-0); and others. (I-0) wherein R1 represents a C1-C6 alkyl group, a C2-C6 alkenyl group, a C2-C6 alkynyl group or a C3-C6 cycloalkyl group; R2, R3, R4 and R5 independently represent a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halo-C1-C6-alkyl group, a C1-C6 alkoxy group or a halo-C1-C6-alkoxy group; R6 represents a hydrogen atom or a C1-C6 alkyl group; R7a represents a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halo-C1-C6-alkyl group, a C1-C6 alkoxy group, a hydroxy-C1-C6-alkyl group, -Q2-N(R1c)R1d or a nitrogenated heterocyclic group; R8a represents a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halo-C1-C6-alkyl group, a C1-C6 alkoxy group or a hydroxy-C1-C6-alkyl group; or R7a and R8a may together form a C2-C6 alkylene group, or R7a, R8a and a ring atom to which R7a and R8a are attached may together form a spiro ring or a bicyclo ring; and X and Y independently represent a methine group or a nitrogen atom. The compound has an excellent inhibitory activity on Wee1 kinase and therefore exhibits an inhibitory activity on the proliferation of a cell and an additive/synergistic effect with a different anti-cancer agent. Therefore, the compound is useful in the medical field.