| 摘要 |
<p>Disclosed is the use of an attenuated rotavirus strain from a G1 serotype in the preparation of a composition for inducing an immune response against rotavirus infection from the G1 and at least two of the non-G1 rotavirus serotypes selected from the group consisting of: G2, G3, G4 and G9 serotypes, wherein the attenuated rotavirus strain is a single rotavirus variant, or substantially a single rotavirus variant, having a VP4 gene comprising, in the nucleotide sequence, an adenine base (A) at positions 788 and 802 and a thymine base (T) at position 501 from the start codon; and wherein the VP7 gene comprises, in the nucleotide sequence, a thymine.</p> |
