CUSTOMIZING STEM CELL-DERIVED CARDIOMYOCYTES FOR TRANSPLANTATION

摘要

The present invention relates to methods of customizing the biological activity (e.g. rhythmic firing rate) of cardiomyocytes derived from pluripotent or multipotent stem cells, followed by transplantation to modify cardiac functions in vivo (e.g. to augment or attenuate the heart rate by modifying the cellular excitability of recipient cells).