发明名称 |
COMPOSITIONS AND METHODS FOR DETECTING AND MODULATING CELL DEATH BY A TRANSLATION REGULATED GENE EXPRESSION SYSTEM |
摘要 |
The technology relates to a nucleic acid expression cassette comprising a TR element encoding an mRNA molecule that is translated in stressed and/or dying cells, and a nucleotide sequence operably linked to the TR element, that is a first open reading frame (ORF) sequence and encodes a polypeptide or a fragment thereof and is co-translated with the TR element. The technology further relates to mammalian cells and a transgenic animal comprising such expression cassette. Further included are kits comprising the expression cassette, and methods for determining toxicity, and killing a target cell |
申请公布号 |
WO2009023517(A3) |
申请公布日期 |
2009.04.30 |
申请号 |
WO2008US72465 |
申请日期 |
2008.08.07 |
申请人 |
WAYNE STATE UNIVERSITY;CARLOCK, LEON;CYPHER, MARIA |
发明人 |
CARLOCK, LEON;CYPHER, MARIA |
分类号 |
C12N15/82;A01H5/00 |
主分类号 |
C12N15/82 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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