HEPARANASE C-TERMINAL DOMAIN, SEQUENCES DERIVED THEREFROM, SUBSTANCES DIRECTED AGAINST SAID DOMAIN AND USES THEREOF AS MODULATORS OF HEPARANASE BIOLOGICAL ACTIVITY

摘要

The present invention relates to an isolated and purified amino acid sequence derived from the C-terminal domain of heparanase that modulates heparanase biological activity. More specifically, the sequence of the invention comprises amino acid residues 413 to 543 of human heparanase or any fragment, peptide, mutant, derivative and variant thereof. The invention further provides modulators of heparanase biological activity that may be amino acid sequences derived from heparanase C-terminal domain or substances which bind to this sequence. The sequences of the invention as well as heparanase modulators are specifically applicable in compositions and methods for the treatment of subjects suffering of heparanase associated disorders.