Single IFN-beta fused to a mutated lgG Fc fragment

摘要

The invention relates to a protein comprising a single IFN-beta fused to a mutated IgG Fc domain containing two subunits, wherein the first subunit comprises a mutated IgG Fc arm not linked to a IFN-beta protein, and the second subunit comprises a mutated IgG Fc arm linked to a single IFN-beta protein, and wherein said mutated IgG Fc domain is an immunoglobulin gamma-1 Fc domain and wherein said Fc domain comprises at least five mutations.