SURFACE COATING TO PREVENT CATION LEACHING

摘要

The present invention concerns a syringe to be filled with a pharmaceutical preparation, characterized in that the barrier effect for all the cation elements is inferior or equal to 250 ng/cm2, preferably inferior or equal to 200 ng/cm2, more preferably inferior or equal to 150 ng/cm2. It also concerns a method to prepare such a syringe comprising the steps of: creating an homogeneous and continuous inner oil layer inside a syringe, exposing said inner oil layer to an oxidative plasma gas, said oil being a non reactive oil.