Use of an oligopeptide comprising a specific amino acid-sequence for the diagnosis or therapy of a pathological condition in a mammal, preferably human, where the condition is identified by angiogenic processes

摘要

Use of an oligopeptide comprising an amino acid-sequence is claimed. Use of an oligopeptide comprising an amino acid-sequence Thr-Leu-Thr-Tyr-Thr-Trp-Ser or Thr-Leu-Thr-Tyr-Thr-Trp-Ser-Gly-Gly-Ser, is claimed Independent claims are included for: (1) an oligopeptide compound with paramagnetic particles containing a paramagnetic isotope such as e.g. 1 5> 7>-gadolinium, 5 5>-manganese or 5 6>-iron or a mixture of different materials, which collectively exhibit a paramagnetic characteristic; (2) use of a peptide of any length comprising an amino terminal; (3) coupling of an oligopeptide to a peptide of any length; (4) a carboxy-terminal coupling of metal chelator at oligopeptide, whose amino terminal end contains an amino acid sequence; (5) bonding of radioactive isotopes of metal ions to coupled metal chelators, or other radioactive isotopes to oligopeptide, whose amino terminal end contains an amino acid sequence or a peptide; (6) use of a peptide coupled compound, in which the peptide sequences contain an amino acid terminal or a coupling, and carry a therapeutic agent; and (7) use of a pharmaceutical preparation comprising the materials. ACTIVITY : Cytostatic; Angiogenesis inhibitor. MECHANISM OF ACTION : Proteolytic modified collagen IV binder.