发明名称 |
RECEPTOR ANTAGONISTS FOR TREATMENT OF METASTATIC BONE CANCER |
摘要 |
The invention provides methods of treating bone cancer, particularly metastatic bone cancer, by administering an IGF-IR antagonist and/or a PDGFRalpha antagonist. The invention also provides antibodies that bind to human PDGFRalpha and neutralize activation of the receptor. The invention further provides a methods for neutralizing activation of PDGFRalpha, and a methods of treating a mammal with a neoplastic disease using the antibodie alone or in combination with other agents.
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申请公布号 |
US2009110678(A1) |
申请公布日期 |
2009.04.30 |
申请号 |
US20060917890 |
申请日期 |
2006.06.19 |
申请人 |
IMCLONE SYSTEMS INCORPORATED;UNIVERSITY OF WASHINGTON |
发明人 |
LUDWIG DALE L.;PLYMATE STEPHEN R. |
分类号 |
A61K39/395;A61K31/337;A61K31/704;A61P35/00;C12N1/19;C12N5/10;C12N15/13;C12N15/63 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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