COMBINED INHIBITORS OF CYCLOOXYGENASE AND SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) (VASCULAR ADHESION PROTEIN, VAP-1)

摘要

Compounds are disclosed which inhibit both semicarbazide-sensitive amine oxidase (SSAO) activity and cyclooxygenase (COX) activity. The compounds combine residues or pharmacophores of SSAO inhibitors with residues or pharmacophores of COX inhibitors in order to create the dual inhibitors. Methods of treatment of diseases, such as inflammation, are also disclosed.