BOROPROLINE COMBINATION THERAPY FOR CANCER

摘要

The present invention relates to methods and compositions for treating a subject having cancer comprising administering an effective amount of pemetrexed and a compound of formula (I): PR, wherein P is a targeting group which binds to the reactive site of a post proline-cleaving enzyme, and wherein R is a reactive group which reacts with thre reactive site of a post proline-cleaving enzyme. Particularly preferred compound of Formula (I) are boroproline compounds, such as Ile-boroPro and Val-boroPro.